We are studying genetic factors of the diseases of bone and joint. The main feature of our lab is to study spinal diseases, monogenic and polygenic diseases simultaneously and comprehensively by starting from human diseases. There are many intractable diseases in the monogenic diseases of the locomotive system, including skeletal dysplasia. We have discovered 25 disease genes so far. The polygenic diseases of the locomotive system include osteoarthritis osteoporosis and disc degeneration. We are tackling on development of innovative methods of diagnosis and treatment of the diseases based on identification of their susceptibility genes. Through the analysis of the genes, we are trying to clarify the mechanism of growth and development of the locomotive system.

Research Areas

1. Epidemiology, radiology, metabolic changes in skeletal fluorosis
2. Primary hyperparathyroidism in Indians: implications for disease understanding
3. Vitamin D deficiency in Indians
4. Normal BMD for Indians
5. Bone health of Adults and Senior Citizens
6. Bone health of children
7. Risk factors for osteoporosis
8. Drug trials

Main Research Fields

• Medicine, Dentistry & Pharmacy

Related Research Fields

• Biological Sciences

Keywords

• Bone and joint disease
• genome
• Association study
• Genetic disease
• Intractable disease